China wholesale Active Pharmaceutical Ingredients - Epigallocatechin gallate EGCG 50-98% CAS 989-51-5 Green Tea Extract – Hande

Product Informations

Glabridin is a kind of flavonoids extracted from a precious plant called licorice. Glabridin is known as “whitening gold” because of its powerful whitening effect, which can eliminate free radicals and melanin at the bottom of the muscle. It is a skin whitening and anti-aging holy artifact.
1. Cosmetic Effects of Glabridin
1. Whitening and brightening
Studies have shown that glabridin can penetrate deep into the inner layer of the skin and exert its high-efficiency skin care activity, effectively inhibiting the activity of various enzymes in the process of melanin production, especially the activity of tyrosinase. Experiments have found that licorice has an inhibitory effect on tyrosinase, and the IC50 value of glabridin for melanin inhibition is very low, which is 232 times that of the king of whitening—vitamin C. Regarding the inhibitory mechanism of Glycyrrhizin on tyrosinase, we speculate that it may be because Glycyrrhizin may form a hydrogen bond with the active center of tyrosinase, and it is firmly stuck at the entrance of tyrosinase, making synthesis The raw materials of melanin cannot get in, and the semi-finished products of melanin cannot come out, which reduces the production of melanin.
2. Antioxidant skin brightening
Glycyrrhiza has a strong scavenging effect on free radicals, and its antioxidant and brightening effect is strong. The antioxidant activity of licorice was determined by the cytochrome P450/NADPH oxidation system in liver microsomes as an in vitro antioxidant experimental model. Biological macromolecules (low-density lipoprotein LDL, DNA) and cell walls are oxidatively damaged by free radicals, which can play a role in delaying cell aging.
3. Fade redness and brighten skin
Glabridin can effectively reduce skin inflammation caused by external stimuli, and has obvious effect on reducing erythema on the skin. Glabridin can improve the phagocytic function of phagocytes, regulate the number and function of lymphocytes, and inhibit the formation of IgE antibodies. It has been reported in the literature that licorice can be used to reduce the corticosteroid administration of infectious skin diseases, and it is estimated that licorice has a corticosteroid-like effect.
2. Application of Glycyrrhiza in cosmetics
Glycyrrhizin has excellent anti-inflammatory, antioxidant and anti-melanin formation effects, so it is used as an ingredient in various cosmetics and medical care products (such as creams, lotions, shower gels, etc.). It can be made into a whitening cream, a patented product of which is already on the market. In cosmetics, in order to achieve the whitening effect, the recommended dosage of the patent is 0.001-3% of licorice, preferably 0.001-1%. With glycerol 1:10, low temperature added. Topical licorice can inhibit the formation of melanin, it has excellent tyrosinase inhibitory activity, can prevent skin tanning, line spots and sunburn.

Product Parameters

COMPANY PROFILE
Product Name	Glabridin
CAS	59870-68-7
Chemical Formula	C20H20O4
Brand	Hande
Manufacturer	Yunnan Hande Bio-Tech Co., Ltd.
Country	Kunming, China
Established	1993
BASIC INFORMATION
Synonyms	4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol; 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol
Structure
Weight	324.37
HS Code	N/A
Quality Specification	Company Specification
Certificates	N/A
Assay	N/A
Appearance	White powder
Method of Extraction	Glycyrrhize glabra L.
Annual Capability	Customized according to customer needs
Package	Customized according to customer needs
Test Method	UV
Logistics	Multiple transports
Payment Terms	T/T, D/P, D/A
Other	Accept customer audit all the time; Assist clients with regulatory registration.